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Folinic acid CAS 58-05-9

Folinic acid CAS 58-05-9
Folinic acid CAS 58-05-9
Folinic acid Quick Details:

Folinic acid (Leucovorin), chemical name N-[4-[(2-amino-5-formyl-1,4,5,6,7, 8-hexahydro-4-oxo-6-pteridine) methyl] amino] benzoyl l-glutamate, has been widely used in combination chemotherapy for cancer.Leucofolic acid enters the body through the uptake and absorption of folate.Once inside the cell it is rapidly metabolized to 5-methylene tetrahydrofolate.5-methylene tetrahydrofolate is the active form of folic acid and can be involved in the single carbon transfer reaction from uracil to thymine.Folic acid thus prevents the formation of tetrahydrofolate from being blocked by folic acid antagonists.

  • Product Name:Folinic acid
  • CAS: 58-05-9
  • MF: C20H23N7O7
  • MW:473.44
  • EINECS:200-361-6
  • Product Categories: Pharmaceutical Raw Materials
Folinic acid Specification:
Items Specifications
Appearance Off-white to greenish yellow powder
Heavy Metals ≤50ppm
Water content ≤12.0%
Specific optical rotation +14.5°- +20.5°
Individual impurity ≤1.0%
Total impurities ≤2.5%
Purity ≥ 97.5%
Folinic acid Application:

Purpose: Leucovorin (calcium leucovorin) is a special form of reduced folate (Folate). High-dose leucovorin intervention given to CFD children can improve their neurological and developmental abnormalities.Abnormal folic acid metabolism is associated with autism in children.Gene polymorphisms in folate-related pathways may lead to abnormal folate metabolism.Studies have found that supplementing with folic acid before birth and during conception reduces the risk of autism in offspring.

Application: Levovlein is used as an antitumor antidote and as an adjutant against giant young cell anemia. Its dose is 1/2 of that of leucovlein. Levovlein can participate in the reaction using folate as a carbon source without being reduced by dihydrofolate reductase, and it can pass through cell membrane either actively or passively.

Levovinic acid has the same basic function as folic acid, but the effect is better than folic acid. At the same time, levovinic acid also has the effect of stimulating the growth and maturity of white blood cells, and can improve megaloblastic anemia.

Folinic acid Usage:

Nutritional supplements for pregnant women

Folinic acid Package:

100g/bag, 500g/bag, 10kg /carton, 25kg/carton, 50kg/bag

Folinic acid Storage:

Keep the seal and keep it under low temperature and dry condition.


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